Modafinil Tablets Improve Cognitive Function
Modafinil tablets improve cognitive function in a number of ways. They increase attention, boost memory and help with creative thinking. They also improve planning, decision making and spatial working memory. They also improve the speed of digit span and visual pattern recognition memory, as well as stopping reaction time in a stop-signal task.
Increased attention
The FDA-approved wake-promoting medication buy modafinil australia has demonstrated promising efficacy in a variety of neurological and psychiatric disorders, including treatment-resistant depression, ADHD, and schizophrenia. Modafinil’s unique profile of neurochemical effects has led to speculation that it exerts pro-cognitive effects in addition to its established stimulant actions on arousal and activity.
A number of studies in animal models and human fMRI have shown that modafinil improves cognitive function, specifically working memory (WM) and episodic memory, as well as processes requiring cognitive control. These improvements in cognitive functioning appear to be related to direct action of modafinil on fronto-cortical circuits that modulate attention and WM.
Several studies have found that modafinil increases performance on a digit span test and other measures of WM. The improvement may be due to an increased efficiency of WM and/or inhibition processes. These effects are correlated with changes in WM-related cortical activity, notably in the medial prefrontal cortex and anterior cingulate cortex.
Another study of adolescent patients with schizophrenia showed that a single modafinil 100 mg dose improved performance on a reversal learning task, as well as a version of the Tower of London, in comparison to placebo. This was accompanied by a reduction in the temporal correlation of BA 46 activity with the number of correct responses and a trend toward improved performance on a delayed visual recognition memory task.
Increased memory
In a series of studies using low-resolution brain electromagnetic tomography (LORETA), Saletu et al found that Modalert Tablet enhances the performance of healthy young adults on various memory and attention tasks. In a double-blind study, participants received either placebo or 100 mg or 200 mg modafinil before performing a series of cognitive tests.
The modafinil group showed a greater improvement in the letter-number span test than the placebo group. The modafinil group also performed better on a lexical decision task. The improvements in memory and attention seen with modafinil may be related to its effects on dopamine levels.
Other studies have found that modafinil improves cognitive performance in non-sleep deprived individuals. In one placebo-controlled, single-dose trial of emergency department physicians after an overnight shift, modafinil significantly improved digit span, spatial planning, and SSRT performance compared with placebo. It also enhanced working memory performance without a speed-accuracy trade-off in a delayed matching to position task. It also improved vigilance and perceptual and arithmetic performance in a sleep-deprived environment (Pigeau et al, 1996).
Modafinil has been evaluated in several medical and psychiatric conditions that are currently treated with stimulants, such as multiple sclerosis fatigue syndrome, chronic fatigue syndrome, idiopathic Parkinson’s disease, narcolepsy, treatment-resistant depression, and attention deficit hyperactivity disorder (ADHD). The results of these studies have been generally positive, but more comprehensive reviews can be found in Ballon and Feifel (2006).
Increased creativity
Modafinil’s (Modawake 200) benefits in terms of cognitive enhancement have been well established in a number of studies. The drug has been shown to improve performance in tasks involving memory and attention. These improvements are most consistent for tasks requiring long-term memory and the ability to learn and problem-solve. Modafinil has also been shown to increase creativity in some studies. However, these effects vary according to the type of task.
In a recent study, 60 healthy young adult male volunteers were given either placebo or a single dose of modafinil before performing a series of tasks that tested memory and attention. They were also asked to complete several tasks assessing creativity. All tasks except one were rated on a visual analogue scale. Subjects on modafinil reported that they found the tasks significantly more pleasurable than those on placebo. This suggests that the drug has a reinforcing effect on the cognitive tasks and may help to explain why it is so helpful for memory and attention.
Although the results from this study support the hypothesis that modafinil enhances cognition, further research is needed to determine its precise mechanisms of action. Modafinil is a schedule IV controlled substance, and is often purchased illegally on the black market by white-collar workers. It has been linked to a number of side effects, including headache and insomnia. It is also a potential drug of abuse, and is often combined with alcohol or cocaine to produce a more pronounced effect.
Increased learning
A variety of behavioral studies indicate that modafinil improves learning in a number of tasks. For example, a series of studies in rodents demonstrated that modafinil enhances working memory performance and the processing of contextual cues.
In addition, several studies have indicated that modafinil has pro-cognitive effects in healthy humans. For instance, one study found that participants given modafinil performed better on a letter-number span task than those who received placebo. Another study showed that the cognitive improvement associated with modafinil was related to increased activation of the left BA 46 region of the brain. Read More Blog…
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